Mesquite Bay is the northern most bay in the Coastal Bend region. It is home to the much debated Cedar Bayou. Cedar Bayou is a natural pass through St. Joseph's and Island that is periodically been opened by hurricanes through out history. There is a current push to dredge Cedar Bayou to create a permanent pass to the Gulf of Mexico to enhance water flow and fish traffic through the bay system.
Surrounded by tidal lakes and marshes, Mesquite Bay is well know for its redfish, trout and flounder populations. Bordered by the Aransas Wildlife Refuge to the west and uninhabited St. Joseph and Matagorda Islands to the west, access to Mesquite Bay is limited, keeping fishing pressure down, compared to other area bays.